Cancer Fighting Mechanisms of CO2 Baths
CO2 baths are very effective for improving many health parameters but this is an interesting study about cancer, hypoxia and apoptosis. Below is an excellent study showing the power of carbon dioxide.
Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo
We have previously reported that transcutaneous CO2 induces mitochondrial apoptosis and decreases lung metastasis by reoxygenating sarcoma cells.
Hypoxia, a common feature of malignant tumors, occurs in numerous solid tumors.
The benefits of carbonated spa (carbon dioxide; CO2 therapy) have long been known in Europe. CO2 therapy is believed to an effective treatment for cardiac diseases and skin problems , . The therapeutic effects of CO2 are mediated by an increase in blood flow and microcirculation, nitric oxide-dependent neocapillary formation, and an increase of partial pressure of O2 in the local tissue known as the Bohr effect. The Bohr effect is represented by a rightward shift of the O2–hemoglobin dissociation curve with increasing pCO2 or decreasing pH . We have previously demonstrated in vivo that transcutaneous CO2 leads to increased O2 release from red blood cells, causing an “Artificial Bohr Effect”
In osteosarcoma, transcutaneous CO2 also decreases the incidence of hematogenous metastases to the lungs by reducing hypoxia.
In summary, this is the first report to show that transcutaneous CO2 suppresses growth of primary human SCC and their lymphogenous metastasis to the regional lymph nodes by making their environment less hypoxic and increasing mitochondrial apoptosis. Our present findings indicate that transcutaneous CO2 decreases the malignant potential of SCC with few side effects.